Using aspirin for the treatment of acne is a bad idea. Aspirin, also known as acetylsalicylic acid, is an oral medication used to reduce pain, fever, or inflammation. It cannot unclog the skin pores, cannot reduce sebum excretion, and has no proven effect on preventing future acne breakouts.
Aspirin contains acetylsalicylic acid. Compound that is made through a chemical reaction between salicylic acid and acetic acid (=vinegar). Its effect is very different from that of salicylic acid, known as one of the best anti-acne ingredients.
One of the main advantages of salicylic acid is that it is fat-soluble (lipophilic). This allows it to penetrate to the depth of the skin's oil glands, unclogging the pores and reducing oil production. On the other, aspirin is soluble in water, a significant downside for the "anti-acne" product.
Acetylsalicylic acid, especially when used in a DYI mask, can be irritating and lead to redness and flaking. It isn't really treating or preventing breakouts. Used in a mask, aspirin can be absorbed into the blood circulation and cause systemic side effects. Aspirin can cause systemic side effects. In people who are allergic to ibuprofen or naproxen, aspirin can trigger bronchospasm.
Aspirin should not be used by children or teens with common or flu symptoms, as this has been linked with Reye's syndrome.
Salicylic acid, benzoyl peroxide treatment, and retinol-based treatment creams are used for decades in acne treatment—They are effective, safe, and very affordable. Don't bother crushing up aspirin and spreading that on your face—it'll only do more harm than good.
If you would like to use a face mask to treat your acne face mask, the best options will be clay masks.