The Progesterone-based Mirena's IUD can definitely cause acne breakouts. Anything hormonal has the ability to affect the glands that secrete sebum and cause acne. Although the risk for severe acne caused by IUDs is small there is a considerable number of reports of women with IUD triggered acne, especially on the chin and jawlines. Saying that, dermatologists do not recommend hormone-eluding IUDs to women who are acne-prone. A copper IUD is your best choice if you want an IUD and you tend to get acne.