Yes. Kyleena can cause acne. There are two major types of IUDs (Intrauterine birth control devices). Copper IUDs and hormone-based IUDs. Kyleena is one of the hormone-based IUDs. Other examples are Mirena, Liletta and Skyla.)
Kyleena is coated with levonorgestrel which is a type of progesterone. Progesterone is a hormone that the body secretes in high amounts during pregnancy. Hormones that are similar to progesterone make it difficult for a fertilized egg to implant into the uterine wall and start a pregnancy.
Kyleena same as the other Progesterone-based IUDs were found to be associated with worsened rates of acne compared to oral contraceptive pills and copper-based IUDs. There have been several cases reported in the literature of severe acne after progestin-based.