Pantothenic acid (vitamin B5) for acne treatment

Pantothenic acid (vitamin B5) for acne treatment

Clinical researchers have found that specific vitamins and minerals, when taken in the proper doses, can be beneficial to anti-acne skincare routines. It is believed that taking Pantothenic Acid (B5) can be helpful with acne treatment.

What is Pantothenic Acid?

The main role of pantothenic acid (B5) in the body is to convert fat, protein, and carbohydrates into energy, which helps maintain healthy hair, skin, and eyes. It was also shown to increase the breakdown of skin oils, which reduces overall oil and sebum production and reduces stress levels.

How Does Pantothenic Acid Help with Acne?

  1. Through the metabolism of CoA, pantothenic acid promotes the breakdown of sebum in the skin's oil glands.
  2. Pantothenic acid (B5) was also shown to improve epidermal barrier function, which in turn helps to reduce acne breakouts.
  3. Pantothenic acid is believed to support stress reduction, which may indirectly aid acne.

Is there clinical research vitamin B5 and Acne?

Yang et a. found that volunteers with acne who took a daily oral dose of a pantothenic acid-based dietary supplement had less acne than those who took a placebo tablet. This study showed that there was a 67% reduction in the number of acne lesions after 12 weeks of supplementation.

Is pantothenic acid safe to use?

Vitamin B-5 supplements are water-soluble. As with other water-soluble vitamins, the urinary tract system would flush any excess of pantothenic acid. The US NIH site, confirms that pantothenic acid is safe, even at high doses. That said, taking very high doses of pantothenic acid supplements (10,000 mg /day) can cause an upset stomach and diarrhea and change the color of the urine to bright yellow.

Are there any know interactions with pantothenic acid?

The NIH confirms that pantothenic acid is not known to interfere or interfere with any medicines.

How much pantothenic acid should one take?

There are currently no formal recommendations as to what dosage of vitamin B5 you should take to treat acne. A few studies that looked into acne treatment with pantothenic acid suggested a mega-dose of Vitamin B5 of 2-4 grams a day. Others believe that a starting dose of 250 mg per day would be more appropriate. If needed, this dose can be increased to 500mg per day (2 capsules).

What is the best form of pantothenic acid?

Many complain about the bulkiness and after taste of the regular pantothenic acid tablets. Vegetable capsules are a much more convenient way to take pantothenic acid supplements. These capsules allow taking the full needed dose in one capsule a day. These capsules are much easier to swallow than regular tablets and don't leave an aftertaste. If the capsules are too big for you, they can also be opened and sprinkled on food.

Which type of pantothenic acid supplement should I take?

For best results, pantothenic acid should be combined with a small amount of Vitamin B1. Adding B1 improves the absorption of B5 in our gastrointestinal system. Adding other vitamins such as vitamins A, B1, B2, and B3 and the minerals zinc, selenium, and chromium are believed to enhance the effect of b5 on the skin and help reduce acne breakouts.

More info: The best vitamins and minerals for people with acne


Yang et al. A Randomized, Double-Blind, Placebo-Controlled Study of a Novel Pantothenic Acid-Based Dietary Supplement in Subjects with Mild to Moderate Facial Acne. (Dermatol Ther. (Heidelb.). 2014 Jun; 4(1): 93–101.

Kelly GS. Pantothenic Acid. Monograph. Altern. Med Rev. 2011;16(3):263–274.

Kobayashi D, Kusama M, et al. The effect of pantothenic acid deficiency on keratinocyte proliferation and the synthesis of keratinocyte growth factor and collagen in fibroblasts. J Pharmacol. Sci. 2011;115(2):230-4.

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