Best Vitamin supplements for acne scars.

Some vitamin supplements are specially formulated for people with acne and acne scars. These vitamin and mineral combinations will usually contain the correct amount of vitamins (especially A and B5), and the correct amount of Zinc, with less of the Biotin and Vitamin E that are shown to counteract the beneficial effect of vitamin A and B5 on acne. Check this link for more info.

The efficacy of wound healing is critical to the way the skin heals after trauma and the amount and type of scarring. A recent group to researches (Nutrition and Wound Healing, Barchitta M, and Maugeri A. J. Mol. Sci. 2019, 20, 1119), review the scientific evidence relating nutrition to wound healing.

The authors found that vitamins were the most investigated micronutrients in the wound healing process. They concluded that there is strong evidence that Vitamin A deficiency hurts the skin immune system function during the inflammatory phase. It also decreases the renewal of the upper layer of the skin (epithelialization), collagen synthesis that is crucial to the restoration and repair of the second layer of the skin (dermis), and the way scar tissue is formed. (granulation tissue development) in the remodeling phases [1].

Vitamin A supplements for Acne Scars

Vitamin A seems to modulate the renewal of damaged skin capillaries, melanocytes, and fibroblasts by binding to retinoic acid receptors [2]. There is also evidence that vitamin A supplements counteract the delay in wound healing caused by corticosteroids [3].

Vitamin B Supplements for Acne Scars

Vitamins B1 (thiamine), Vitamin B2 (riboflavin), Vitamin B6 (pyridoxine), Vitamin B9 (folic acid), Vitamin B5 (pantothenic acid), and Vitamin B12 (cobalamins), are essential factors in enzyme reactions involved in wound healing. Thiamine (B1), riboflavin (B2), pyridoxine (B6), and cobalamins (B12) are also required for the synthesis of collagen [4].

Vitamin C Supplements for Acne Scars

Vitamin C is also required for optimal wound healing. It was found that he has a role in cell migration, collagen synthesis, antioxidant response, and angiogenesis. During collagen synthesis, vitamin C forms extra-bounds between collagen fibers that increase the stability and strength of the dermis [5]. Vitamin C is also essential to counteract free radicals in damaged cells, while its deficiency might increase the fragility of new vessels [6].

Vitamin E Supplements for Acne Scars

Although most vitamins show beneficial effects in wound healing, vitamin E oral supplements might negatively affect collagen synthesis [7]. Moreover, vitamin E appears to counteract the benefits of vitamin A supplementation in wound management [8].


1. Stadelmann, W.K.; Digenis, A.G.; Tobin, G.R. Impediments to wound healing. Am. J. Surg. 1998, 176, 39S–47S.
2. Reichrath, J.; Lehmann, B.; Carlberg, C.; Varani, J.; Zouboulis, C.C. Vitamins as hormones. Horm. Metab. Res.2007, 39, 71–84.
3. Wicke, C.; Halliday, B.; Allen, D.; Roche, N.S.; Scheuenstuhl, H.; Spencer, M.M.; Roberts, A.B.; Hunt, T.K.Effects of steroids and retinoids on wound healing. Arch. Surg. 2000, 135, 1265–1270.
4. Russell, L. The importance of patients’ nutritional status in wound healing. Br. J. Nurs. 2001, 10, S42–S49.
5. Harris, C.L.; Fraser, C. Malnutrition in the institutionalized elderly: The effects on wound healing. Ostomy. Wound Manag. 2004, 50, 54–63.
6. Shepherd, A.A. Nutrition for optimum wound healing. Nurs. Stand. 2003, 18, 55–58.
7. Mazzotta, M.Y. Nutrition and wound healing. J. Am. Podiatr. Med. Assoc. 1994, 84, 456–462.
8. Trujillo, E.B. Effects of nutritional status on wound healing. J. Vasc. Nurs. 1993, 11, 12–18.

More info on pantothenic acid for people with acne.

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